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Activity Date: 04/26/2022

AAPP 2022 registration is closed.

Session Time and Location

The live session is complete.

Target Audience

If you are a pharmacist, nurse practitioner, or other health care professional involved in the comprehensive medication management of individuals living with mental health and/or substance use disorders, we invite you to participate in this online course.

Session Summary

CPNP members share their experiences dealing with clinical problems.
Parkinsonism-Hyperpyrexia Syndrome
Joseph Cusimano, PharmD, BCPP
Parkinsonism-hyperpyrexia syndrome (PHS) is a rare but potentially lethal syndrome that can occur when antiparkinson therapy is abruptly stopped or decreased. The clinical features of PHS and a better-known, also medication-related, syndrome called neuroleptic malignant syndrome (NMS) overlap substantially, which may delay accurate diagnosis and effective treatment. In the present case, the team was unfamiliar with PHS, leading to an initial misdiagnosis as NMS due to the presence of a second-generation antipsychotic on the patient’s medication regimen.
Antipsychotic-Induced Hyperprolactinemia: An Approach to Medication Management
Shadi Doroudgar, PharmD, APh, BCPS, BCGP, BCPP
Hyperprolactinemia has been associated with multiple long-term complications. Drug-induced hyperprolactinemia is an important topic that deserves greater clinical attention. Antipsychotic medications are the most common cause of pharmacologically induced hyperprolactinemia. Identification and appropriate management of hyperprolactinemia is essential given that it is a common side effect of antipsychotic medications. 
Clozapine: Removing the Smoke Screen
Carolina Liriano, PharmD
Clozapine is an antipsychotic indicated for treatment resistant schizophrenia. Due to the many risks associated with use, close monitoring is required. The polycyclic aromatic hydrocarbons found in cigarette tar is a known inducer of clozapine metabolism. Considering that upwards of 80% of patients with schizophrenia are smokers, this interaction becomes very relevant to this patient population. In addition, upon inpatient admission to non-smoking facilities clozapine levels may rise in those who are forced to quit during their hospitalization. This clinical pearl reviews current literature to help quantify the clinical significance of the interaction between clozapine and smoking, in addition explores current recommendations for management.

Course Requirements

To receive ACPE credit for the live session at the Annual Meeting, you must:

  • Sign in (or create a FREE account).
  • Register for this course.
  • Attend and participate in the entire session and reflect upon its teachings.
  • Complete the evaluation at the end of the activity.
  • Provide the necessary details in your profile to ensure correct reporting by AAPP to CPE Monitor.
Upon successful completion, ACPE credit is reported within 24 hours to CPE Monitor although transcripts can be retrieved by participants online in their ACPE Transcript.

Faculty Information and Disclosures

Joseph Cusimano, PharmD, BCPP
Shadi Doroudgar, PharmD, APh, BCPS, BCGP, BCPP
Carolina Liriano, PharmD

View biographical information and disclosures

Learning Objectives

Parkinsonism-Hyperpyrexia Syndrome
  1. Identify the signs, symptoms, and risk factors for parkinsonism-hyperpyrexia syndrome.
  2. Develop a pharmacotherapy plan for mitigating parkinsonism-hyperpyrexia syndrome.
Antipsychotic-Induced Hyperprolactinemia: An Approach to Medication Management
  1. Identify signs and symptoms of hyperprolactinemia in patients treated with antipsychotic medications.
  2. Discuss treatment options for the management of hyperprolactinemia.
Clozapine: Removing the Smoke Screen
  1. Describe and quantify the interaction between smoking and clozapine serum concentration.
  2. Review current recommendations for the management of smoking cessation in clozapine patients.

Continuing Education Credit and Disclosures

Activity Date: 04/26/2022
ACPE Contact Hours: 1
ACPE Number: 0284-0000-22-046-L01-P (Knowledge)
Nursing Credit Reminder: Note that ACPE credit is accepted for certification renewal.

ACPEThe College of Psychiatric and Neurologic Pharmacists is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.

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