Registration Options

Activity Dates: 04/29/2025 - 04/29/2028

Session Time and Location

Date: Tuesday, 04/29/2025

Time: 3:10 PM (view in the schedule)

Room: Regency C-L4

Target Audience

If you are a pharmacist, nurse practitioner, or other health care professional involved in the comprehensive medication management of individuals living with mental health and/or substance use disorders, we invite you to participate in this online course.

Session Summary

This Clinical Pearls session consists of three, 15-minute presentations about unique psych pharmacy patient cases and/or clinical challenges. Each presentation will be recorded, and the three combined sessions are available for 1.0 hour of ACPE credit. 

The Role of Buprenorphine in Restless Legs Syndrome, presented by Alissa Scalise, PharmD, BCPS, BCPP

  1. Describe the role of opioids in treatment of Restless Legs Syndrome (RLS).
  2. Explore two patient cases and identify the benefit of buprenorphine in the treatment of restless legs syndrome.

Summary: Restless Legs Syndrome (RLS) is a challenging neurologic condition that is treated with commonly used CNS pharmacotherapeutics.  Opioid therapy has been used for many years for RLS, but many providers are hesitant given the opioid epidemic. Recent guidelines were released by the American Academy of Sleep Medicine with changes to the treatment algorithm have adjusted the place in therapy for dopamine agonists, a commonly known mainstay of RLS treatment. The importance of opioid therapy in RLS treatment will be highlighted in this clinical pearl, along with a patient case describing how buprenorphine can be a safe alternative to full agonist opioid therapy, highlighting another important clinical use of this important medication.

Pee Attention!: Interpreting Fentanyl Urine Drug Tests, presented by Roisin Sabol, PharmD

  1. Recognize limitations of immunoassay tests to screen for fentanyl use.
  2. Discuss how to interpret quantitative fentanyl tests using patient-specific considerations.  

Summary: Nearly 70% of drug overdose deaths in the United States in 2023 involved fentanyl, underscoring the importance of continued harm reduction efforts to combat the opioid crisis. Urine drug monitoring can be a valuable source of objective information about fentanyl exposure, but this is contingent on appropriate use. As immunoassay and quantitative drug tests are increasingly used in clinical settings, accurate interpretation is essential. Understanding fentanyl’s unique pharmacokinetic and pharmacodynamic properties is foundational to recognizing the complexities and limitations of fentanyl urine drug tests.

Monitoring Methadone: Beyond the EKG, presented by Zoe Karavolis, PharmD, MPH, BCPP, CPH

  1. Describe methadone pharmacology and therapeutic drug monitoring.
  2. Review clinical implications for methadone therapeutic drug monitoring and limitations of split dosing.

Summary: Methadone is a first-line treatment option for opioid use disorder; however, it presents significant dosing challenges based on its pharmacokinetic and pharmacodynamic principles. Serum methadone monitoring has been proposed as a tool to guide the interpatient variability that exists with dosing. To date, there is limited literature to support the use of methadone serum monitoring. This clinical pearl will review the clinical implications and potential role for methadone serum monitoring in clinical practice.

Faculty Information

Alissa Scalise, PharmD, BCPS, BCPP
Roisin Sabol, PharmD
Zoe Karavolis, PharmD, MPH, BCPP, CPH

View biographical information

Continuing Education Credit and Disclosures

Activity Dates: 04/29/2025 - 04/29/2028
ACPE Contact Hours: 1
ACPE Number: 0284-0000-25-018-H01-P (Knowledge)
Nursing Credit Reminder: Note that ACPE credit is accepted for ANCC Certification Renewal and AANPCB advanced practice provider content. For specific questions related to your organization's acceptance of ACPE continuing education units, please contact your organization directly.

ACPEThe American Association of Psychiatric Pharmacists is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.

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