Treatment Guidelines: Depression

American Academy of Child & Adolescent Psychiatry

• Clinical practice guideline for the assessment and treatment of children and adolescents with major and persistent depressive disorders (2023)

American Academy of Pediatrics

• Guidelines for adolescent depression in primary care (GLAD-PC): Part I. Practice preparation, identification, assessment, and initial management (2018)
• Guidelines for adolescent depression in primary care (GLAD-PC): Part II. Treatment and ongoing management (2018)

American College of Physicians

• Nonpharmacologic and pharmacologic treatments of adults in the acute phase of major depressive disorder (2023)

American Psychiatric Association (APA) 

• Treatment of patients with major depressive disorder (2010) 

American Psychological Association (APA)

• Clinical practice guideline for the treatment of depression across three age cohorts (2019)

Canadian Network for Mood and Anxiety Treatments (CANMAT)

• Update on clinical guidelines for management of major depressive disorder in adults (2023)

French Association for Biological Psychiatry and Neuropsychopharmacology

• Clinical guidelines for the management of depression with specific comorbid psychiatric conditions (2019)
• Clinical guidelines for the management of treatment-resistant depression (2019)

Institute for Clinical Systems Improvement

• Depression in primary care (2016)  

National Institute for Health and Care Excellence (NICE)

• Depression in adults: recognition and management (2022)
• Depression in children and young people: identification and management (2019)
• Depression in adults with a chronic physical health problem: recognition and management (2009)

The National Centre of Excellence in Youth Mental Health 

• Treating depression in young people (2017)

The Royal Australian and New Zealand College of Psychiatrists 

• Clinical practice guidelines for mood disorders (2020)

Veterans Affairs/Department of Defense

• Management of major depressive disorder (2022)

World Federation of Societies of Biological Psychiatry (WFSBP)

• Treatment of unipolar depressive disorders, Part 2: Maintenance treatment of major depressive disorder (2015)
• Treatment of unipolar depressive disorders, Part 1: Update 2013 on the acute and continuation treatment of unipolar depressive disorders (2013)

Reviewer 1: Amanda Campbell, PharmD, BCPP
Reviewer 2:  Mitchell Crouch, PharmD, BCPP
2025-2026 AAPP Resident and New Practitioner Committee