Treatment Guidelines: Depression

American Academy of Child & Adolescent Psychiatry

• Clinical practice guideline for the assessment and treatment of children and adolescents with major and persistent depressive disorders (2022)

American Academy of Pediatrics

• Guidelines for adolescent depression in primary care (GLAD-PC): Part I. Practice preparation, identification, assessment, and initial management (2018)
• Guidelines for adolescent depression in primary care (GLAD-PC): Part II. Treatment and ongoing management (2018)

American College of Physicians

• Nonpharmacologic and pharmacologic treatments of adults in the acute phase of major depressive disorder (2023)

American Psychiatric Association (APA)

• Treatment of patients with major depressive disorder (2010)

American Psychological Association (APA)

• Clinical practice guideline for the treatment of depression across three age cohorts (2019)

Canadian Network for Mood and Anxiety Treatments (CANMAT)

• Clinical guidelines for the management of major depressive disorder in adults (2016)

French Association for Biological Psychiatry and Neuropsychopharmacology

• Guidelines for the management of patients with partially responsive depression and treatment-resistant depression: Update (2024)
• Clinical guidelines for the management of depression with specific comorbid psychiatric conditions (2019)
• Clinical guidelines for the management of treatment-resistant depression (2019)

Institute for Clinical Systems Improvement

• Depression in primary care (2016)

National Institute for Health and Care Excellence (NICE)

• Depression in adults: recognition and management (2022)
• Depression in children and young people: identification and management (2019)
• Depression in adults with a chronic physical health problem: recognition and management (2009)

The National Centre of Excellence in Youth Mental Health

• Treating depression in young people (2017)

The Royal Australian and New Zealand College of Psychiatrists

• Clinical practice guidelines for the treatment of mood disorders (2020)

Veterans Affairs/Department of Defense

• Management of major depressive disorder (2022)

World Federation of Societies of Biological Psychiatry (WFSBP)

• Treatment of unipolar depressive disorders, Part 2: Maintenance treatment of major depressive disorder (2015)
• Treatment of unipolar depressive disorders, Part 1: Acute and continuation treatment of major depressive disorder (2013)

Reviewer 1: Claire Herbst, PharmD, BCPS, BCPP
Reviewer 2: Austin Smith, PharmD, BCPP
2024-2025 AAPP Resident and New Practitioner Committee