Management of pain in patients with comorbid substance use disorders can be challenging. Providers may be hesitant to use opioid analgesics in patients with a history of substance misuse or those currently receiving substance use disorder treatment. However, these patients may still experience pain and should have their pain adequately treated.

  • How does one treat pain in the setting of comorbid substance use disorders?1-7
  • What are the consequences of suboptimal pain control in the presence of substance use disorder treatment?8-10
  • How to manage pain in the perioperative and postoperative setting for those on medication assisted treatment for opioid use disorder?11-16

Reviewer 1: Brendon Hogan, PharmD, BCPP
Reviewer 2: Rachel B. Barr, PharmD, BCPP
Reviewer 3: Joseph M. Cusimano, PharmD, BCPP
2022-2023 AAPP Resident and New Practitioner Committee


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  13. Mehta D, Thomas V, Johnson J, et al. Continuation of Buprenorphine to Facilitate Postoperative Pain Management for Patients on Buprenorphine Opioid Agonist Therapy. Pain Physician. 2020;23(2):E163-E174. [PubMed]
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