The prevalence of psychiatric disorders has been well documented in individuals with renal disease. Although not robust, data exists to guide medication choices and dosing strategies in patients with renal insufficiency, including those on dialysis.
- What are some of the pharmacokinetic, pharmacodynamic, and physiologic considerations for psychotropic medication use in patients with renal disease?1-3
- Do psychotropic medications require dose adjustments for patients with renal disease?4-7
- How should depression be managed in patients with renal disease?8-14
- Can lithium be used in patients with renal disease?15-17
Reviewer 1: Claire Herbst, PharmD, BCPS, BCPP
Reviewer 2: Roisin Sabol, PharmD
2025-2026 AAPP Resident and New Practitioner Committee
Essential Questions and References
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- Bossola M, Mariani I, Antocicco M, Pepe G, Petrosino A, Di Stasio E. Selective serotonin reuptake inhibitors and symptoms of depression in patients on chronic hemodialysis: a systematic review. J Clin Med. 2024;13(11):3334. [PubMed]
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