Due to the potential for concomitant psychiatric illness and substance use disorders, understanding the potential interactions between psychotropics and drugs of abuse is important.

  • What are the potential drug-drug interactions between illicit drugs and medications?1-3
  • How does cigarette smoking (polycyclic aromatic hydrocarbons) affect medications?4-5
  • What are possible drug interactions in patients that consume alcohol?6-7
  • How do opioids and benzodiazepines interact? What is the clinical significance of the combination?8-10
  • How do drugs of abuse interact with anti-retroviral therapies?11-12
  • How do natural or synthetic cannabis interact with medications?13-18

Reviewer 1: Carley Rainey, PharmD, BCPS
Reviewer 2: Katy L. Zeier, PharmD, BCPP
Reviewer 3: Austin Smith, PharmD, BCPP
2023-2024 AAPP Resident and New Practitioner Committee

References

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  2. Abbott KL, Flannery PC, Gill KS et al. Adverse pharmacokinetic interactions between illicit substances and clinical drugs. Drug Metab Rev. 2020; 52(1): 44-65. [PubMed]     
  3. Lindsey WT, Stewart D, Childress D. Drug interactions between common illicit drugs and prescription therapies. Am J Drug Alcohol Abus. 7th ed. 2012;38(4):334-43. DOI: 10.3109/00952990.2011.643997. PubMed PMID: 22221229.
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  9. McCance-Katz EF, Sullivan LE, Nallani S. Drug interactions of clinical importance among the opioids, methadone and buprenorphine, and other frequently prescribed medications: a review. Am J Addict. 2010;19(1):4-16. DOI: 10.1111/j.1521-0391.2009.00005.x. PubMed PMID: 20132117; PubMed Central PMCID: PMC3334287.
  10. U.S. Food and Drug Administration. FDA Drug Safety Communication: FDA urges caution about withholding opioid addiction medications from patients taking benzodiazepines or CNS depressants: careful medication management can reduce risks. 2017. [Weblink]
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  14. Kong TY, Kim JH, Kim DK, Lee HS. Synthetic cannabinoids are substrates and inhibitors of multiple drug-metabolizing enzymes. Arch Pharm Res. 2018;41(7):691-710. [PubMed]
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  17. Brown JD. Potential adverse drug events with tetrahydrocannabinol (THC) due to drug-drug interactions. J Clin Med. 2020;9(4):919. [PubMed]
  18. Doohan. PT, Oldfield LD, Arnold JC, Anderson, LL. Cannabinoid Interactions with Cytochrome P450 Drug Metabolism: a Full-Spectrum Characterization. AAPS J. 2021 Jun 28;23(4):91. [Pubmed]