Due to the potential for concomitant psychiatric illness and substance use disorders, understanding the potential interactions between medications with illicit and addictive substances is important.
- What are the potential drug-drug interactions between illicit drugs and medications?1-3
- How does cigarette smoking (polycyclic aromatic hydrocarbons) affect medications?4-5
- What are possible drug interactions in patients that consume alcohol?6-7
- How do opioids and benzodiazepines interact? What is the clinical significance of the combination?8-10
- How do drugs of abuse interact with anti-retroviral therapies?11-12
- How do natural or synthetic cannabis interact with medications? 13-18
Reviewer 1: Carly Rainey, PharmD, BCPS
Reviewer 3: Austin Smith, PharmD, BCPP
2024-2025 AAPP Resident and New Practitioner Committee
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- Desai N, Burns L, Gong Y, et al. An update on drug-drug interactions between antiretroviral therapies and drugs of abuse in HIV systems. Expert Opin Drug Metab Toxicol. 2020;16(11):1005-1018. [PubMed]
- Cernasev A, Veve MP, Cory TJ, et al. Opioid use disorders in people living with HIV/AIDS: a review of implications for patient outcomes, drug interactions, and neurocognitive disorders. Pharmacy (Basel). 2020;8(3):168. [PubMed]
- Arellano AL, Papaseit E, Romaguera A, Torrens M, Farre M. Neuropsychiatric and General Interactions of Natural and Synthetic Cannabinoids with Drugs of Abuse and Medicines. CNS Neurol Disord Drug Targets. 2017;16(5):554-566. [PubMed]
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- Brown JD. Potential adverse drug events with tetrahydrocannabinol (THC) due to drug-drug interactions. J Clin Med. 2020;9(4):919. [PubMed]
- Doohan. PT, Oldfield LD, Arnold JC, Anderson, LL. Cannabinoid Interactions with Cytochrome P450 Drug Metabolism: a Full-Spectrum Characterization. AAPS J. 2021 Jun 28;23(4):91. [Pubmed]