Changes in cytochrome P450 (CYP) enzyme metabolism are a common cause of drug-drug interactions. Several psychotropic agents are significantly impacted by CYP interactions or cause interactions by inhibiting or inducing CYP metabolism.
- Is there a list of CYP substrates and interacting medications?1-4
- Where can I find a database with multiple interaction analyses?5-7
- How should I interpret drug-drug interaction studies?8-11
Reviewer 1: Leah Rickert, PharmD, BCPP
Reviewer 2: Danielle Dauchot, PharmD, BCPP
2025-2026 AAPP Resident and New Practitioner Committee
- Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (Updated 2021). Accessed: August 2025. [Weblink]
- Pharmacist's Letter: Cytochrome P450 (CYP) Drug Interactions. Updated May 2024. [Weblink]
- Purchase/subscription required
- FDA. Drug Development and Drug Interactions | Table of Substrates, Inhibitors, and Inducers. Updated 2023. [Weblink]
- Not all inclusive
- FDA. For Healthcare Professionals | FDA’s Examples of Drugs that Interact with CYP Enzymes and Transporter Systems. Table 1 and Table 2. Updated June 2025. [Weblink]
- UpToDate Lexidrug. Updated 2024. [Weblink]
- Purchase/subscription required
- Micromedex. Updated 2024. [Weblink]
- Purchase/subscription required
- Clinical Pharmacology. Updated 2024. [Weblink]
- Purchase/subscription required
- Tornio A, Filppula AM, Niemi M, Backman JT. Clinical studies on drug-drug interactions involving metabolism and transport: methodology, pitfalls, and interpretation. Clin Pharmacol Ther. 2019;105(6):1345-1361. [PubMed]
- FDA. M12 Drug Interaction Studies: Guidance for Industry. August 2024. [Weblink]
- FDA. M12 Drug Interaction Studies: Questions and Answers. August 2024. [Weblink]
- Lee J, Beers JL, Geffert RM, Jackson KD. A Review of CYP-Mediated Drug Interactions: Mechanisms and In Vitro Drug-Drug Interaction Assessment. Biomolecules. 2024 Jan 12;14(1):99. doi: 10.3390/biom14010099. PMID: 38254699; PMCID: PMC10813492. [PubMed]