Changes in cytochrome P450 (CYP) enzyme metabolism are a common cause of drug-drug interactions. Several psychotropic agents are significantly impacted by CYP interactions or cause interactions by inhibiting or inducing CYP metabolism.
- Is there a list of psychotropic agents and their CYP substrates and inducing/inhibiting capabilities?1
- Is there a list of CYP substrates and interacting medications?2
- Where can I find a database with multiple interaction analyses?3-5
- How should I interpret drug-drug interaction studies?6
References
- CYP450 Drug Interactions Table for Psychiatric Medications. Updated 2017. [Weblink]
- Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed: August 2021. [Weblink]
- Pharmacist's Letter: Cytochrome P450 (CYP) Drug Interactions. Updated 2020. [Weblink]
- Purchase/subscription required
- Lexicomp [Weblink]
- Purchase/subscription required
- Micromedex [Weblink]
- Purchase/subscription required
- Tornio A, Filppula AM, Niemi M, Backman JT. Clinical studies on drug-drug interactions involving metabolism and transport: methodology, pitfalls, and interpretation. Clin Pharmacol Ther. 2019;105(6):1345-1361. [PubMed]