Psychiatric Pharmacy Essentials: CYP Substrate/Inducer/Inhibitor List: Psychotropic-focus

Changes in cytochrome P450 (CYP) enzyme metabolism are a common cause of drug-drug interactions. Several psychotropic agents are significantly impacted by CYP interactions or cause interactions by inhibiting or inducing CYP metabolism.

  • Is there a list of CYP substrates and interacting medications?1-4

  • Where can I find a database with multiple interaction analyses?5-7

  • How should I interpret drug-drug interaction studies?8-9

Reviewer 1 Meagan Dean, PharmD
Reviewer 2: Leah Rickert, PharmD, BCPP
Reviewer 3: Austin Smith, PharmD, BCPP
2024-2025 AAPP Resident and New Practitioner Committee

References

  1. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed:August 2024.  [Weblink]
  2. Pharmacist's Letter: Cytochrome P450 (CYP) Drug Interactions. Updated May 2024.  [Weblink]
    • Purchase/subscription required
  3. FDA. Drug Development and Drug Interactions | Table of Substrates, Inhibitors, and Inducers. Updated 2023. [Weblink]
    • Not all inclusive
  4. FDA. For Healthcare Professionals | FDA’s Examples of Drugs that Interact with CYP Enzymes and Transporter Systems. Table 1 and Table 2. Updated June 2024. [Weblink]
  5. UpToDate Lexidrug. Updated 2024.[Weblink]
    • Purchase/subscription required
  6. Micromedex. Updated2024. [Weblink]
    • Purchase/subscription required
  7. Clinical Pharmacology. Updated2024. [Weblink]
    • Purchase/subscription required
  8. Tornio A, Filppula AM, Niemi M, Backman JT. Clinical studies on drug-drug interactions involving metabolism and transport: methodology, pitfalls, and interpretation. Clin Pharmacol Ther. 2019;105(6):1345-1361. [PubMed]
  9. FDA. Clinical Drug Interaction Studies – Cytochrome P450 Enzyme- and Transporter- Mediated Drug Interactions: Guidance for Industry. Jan. 2020. [Weblink]