Changes in cytochrome P450 (CYP) enzyme metabolism are a common cause of drug-drug interactions. Several psychotropic agents are significantly impacted by CYP interactions or cause interactions by inhibiting or inducing CYP metabolism.

  • Is there a list of psychotropic agents and their CYP substrates and inducing/inhibiting capabilities?1
  • Is there a list of CYP substrates and interacting medications?2
  • Where can I find a database with multiple interaction analyses?3-5
  • How should I interpret drug-drug interaction studies?6


  1. CYP450 Drug Interactions Table for Psychiatric Medications. Updated 2017. [Weblink]
  2. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed: August 2021. [Weblink]
  3. Pharmacist's Letter: Cytochrome P450 (CYP) Drug Interactions. Updated 2020. [Weblink]
    • Purchase/subscription required
  4. Lexicomp [Weblink]
    • Purchase/subscription required
  5. Micromedex [Weblink]
    • Purchase/subscription required
  6. Tornio A, Filppula AM, Niemi M, Backman JT. Clinical studies on drug-drug interactions involving metabolism and transport: methodology, pitfalls, and interpretation. Clin Pharmacol Ther. 2019;105(6):1345-1361. [PubMed]
25 Years!