It is not uncommon for patients to be switched from one antipsychotic to another. Chlorpromazine equivalents help guide clinicians in estimating an approximately equivalent dose when transitioning from one antipsychotic to another.
How should I convert doses between different antipsychotics?1-7
What resources are available for identifying kinetic information of various antipsychotic medications?
Antipsychotic Dose Equivalents (based on chlorpromazine)
Generic |
Brand |
Dose Equivalent |
First Generation Antipsychotics |
Chlorpromazine |
Thorazine© |
100 mg |
Fluphenazine |
Prolixin© |
2 mg |
Haloperidol |
Haldol© |
2 mg |
Loxapine |
Loxitane© |
10 mg |
Perphenazine |
Trilafon© |
8 mg |
Pimozide |
Orap© |
2 mg |
Prochlorperazine |
Compazine© |
15 mg |
Trifluoperazine |
Stelazine© |
2-5 mg |
Thioridazine |
Mellaril© |
100 mg |
Thiothixene |
Navane© |
4 mg |
Second Generation Antipsychotics |
Aripiprazole |
Abilify© |
7.5 mg |
Asenapine |
Saphris© |
4 mg1 |
Brexpiprazole |
Rexulti© |
N/A |
Cariprazine |
Vraylar© |
N/A |
Clozapine |
Clozaril© |
100 mg |
Iloperidone |
Fanapt© |
3-4 mg1 |
Lurasidone |
Latuda© |
16 mg1 |
Lumateperone |
Caplyta© |
Unknown |
Olanzapine |
Zyprexa© |
5 mg |
Paliperidone |
Invega© |
2 mg1 |
Quetiapine |
Seroquel© |
75 mg |
Risperidone |
Risperdal© |
1 mg |
Ziprasidone |
Geodon© |
60 mg |
Reviewer 1: Katy Zeier, PharmD, BCPP
Reviewer 2: Megan Sarashinsky, PharmD, BCPP
Reviewer 3: Austin Smith, PharmD, BCPP
2023-2024 AAPP Resident and New Practitioner Committee
References
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