Activity Dates: 06/01/2018 - 04/24/2021
This course is designed for pharmacists and/or other healthcare professionals involved in the medication management of individuals living with psychiatric, neurologic and/or substance use disorders.
Deconstructing the illness of schizophrenia is of particular interest as this heterogeneous disorder may be composed of etiologically distinct disorders with different mechanisms which could all serve as treatment targets for components of the disorder. One specific group with elevated peripheral and central inflammatory response is those with schizophrenia having elevations in antigliadin antibodies (AGA IgG). In addition to high inflammation, this subgroup may be distinct by having lower positive symptoms and high kynurenic acid levels. It remains unclear, however, how these elevations in AGA IgG and immune activation in this subgroup may contribute to the illness and schizophrenia psychopathology; however it may be related to gut permeability or mimicry/cross reactivity to proteins present. This population may represent a subgroup which may have personalized and targeted treatments developed. This talk will discuss the emerging association of inflammation and immune activity in schizophrenia, review the data that helps characterize the subgroup with AGA IgG and present ongoing work for treatment targets and mechanisms of action connecting gluten to schizophrenia. This work suggests that more personalized treatments targeting diet modulation or immune/inflammation may play future roles in schizophrenia treatment.
You will proceed through the following steps to satisfactorily complete this course:
Participants in this course must complete an examination and achieve a score of 70% or greater. Successful completion of the course also requires the completion of a course evaluation. Upon successful completion, ACPE credit is reported immediately to CPE Monitor although transcripts can be retrieved by participants online at https://aapp.org/mycpnp/transcript/acpe.
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Deanna Kelly, PharmD, BCPP
View biographical information and disclosures
The College of Psychiatric and Neurologic Pharmacists is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. This course provides 1.0 contact hour of knowledge-based continuing education credit from CPNP approved programming.
AAPP owns the copyright, is licensed or has received permissions for use of, or is otherwise permitted to use copyrighted materials within any CPE activity. Authors and speakers are required to obtain necessary copyright permissions for content in CPE activities. AAPP complies with copyright laws and regulations.
2018 CPNP Program Committee Disclosures
Elayne D. Ansara, PharmD, BCPP, BCPS |
Jennifer Bean, PharmD, BCPP, BCPS |
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Jolene R. Bostwick, PharmD, BCPS, BCPP Associate Chair & Clinical Associate Professor, Department of Clinical Pharmacy University of Michigan College of Pharmacy Ann Arbor, MI No Relevant Financial Relationships to Disclose |
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Sheila R. Botts, PharmD, BCPP, FCCP Chief of Clinical Pharmacy Research and Academic Affairs Kaiser Permanente-Colorado Aurora, CO Educational Grants, Research Grants or Contracts: Kaiser Permanente Center for Safety and Effectiveness Non-Financial Interests: Board of Pharmacetical Specialties Psychiatric Pharmacy Specialty Council |
Bridget Bradley, PharmD, BCPP |
Austin R. Campbell, PharmD, BCPP |
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Andria F. Church, PharmD, BCPS Assistant Professor Larkin University College of Pharmacy Miami, FL No Relevant Financial Relationships to Disclose |
Kelly N. Gable, PharmD, BCPP |
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Kristen N. Gardner, PharmD Clinical Pharmacy Specialist - Behavioral Health Kaiser Permanente Colorado Denver, CO Employment: Kaiser Permanente Colorado |
Cindy A. Gutierrez, PharmD, BCPP, MS |
Robert J. Haight, PharmD, BCPP |
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Michael Kotlyar, PharmD, MS Associate Professor University of Minnesota Minneapolis, MN No Relevant Financial Relationships to Disclose |
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Megan Maroney, PharmD, BCPP Clinical Associate Professor Ernest Mario School of Pharmacy at Rutgers, the State University of New Jersey Long Branch, NJ External Consultant Activities, Advisory Panels, Speakers Bureaus, etc.: Pharmacy Times, Jannsen Pharmacueticals - Advisory board, Otsuka Pharmaceuticals - Speakers Bureau |
Leigh Anne Nelson, PharmD, BCPP |
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Rosana C. Oliveira, PharmD, BCPP, BCPS Clinical Pharmacy Specialist - Psychiatry South Texas Veterans Health Care System San Antonio, TX No Relevant Financial Relationships to Disclose |
Gerald P. Overman, PharmD, BCPP |
Emma C. Palmer, PharmD, BCPS, BCPP |
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Lindsey Peters, PharmD, BCPS Assistant Professor of Pharmacy Practice Ohio Northern University Ada, OH No Relevant Financial Relationships to Disclose |
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Melody Ryan, PharmD, BCPS, BCGP, FCCP Professor University of Kentucky Lexington, KY No Relevant Financial Relationships to Disclose |
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Kristyn Straw, PharmD, BCPP Mental Health Pharmacist Southern Arizona VA Health Care System Tucson, AZ No Relevant Financial Relationships to Disclose |
Daina Wells, PharmD, BCPP, BCPS |
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Gabriela D. Williams, PharmD, BCPS, BCPP Clinical Pharmacy Specialist, Psychiatry Eskenazi Health Indianapolis, IN No Relevant Financial Relationships to Disclose |
All relevant relationships have been mitigated.
Off-Label Use: This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA (see faculty information and disclosures). The opinions expressed in the educational activity do not necessarily represent the views of AAPP and any educational partners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Disclaimer: Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Presentation-Specific Disclosure: My presentation will include discussion of off-label, experimental, and /or investigational use of drugs or devices: Investigational diet modification for treatment.
It is the policy of AAPP to ensure independence, balance, objectivity, scientific rigor, and integrity in continuing education activities. Those involved in the development of this continuing education activity have made all reasonable efforts to ensure that information contained herein is accurate in accordance with the latest available scientific knowledge at the time of accreditation of this continuing education activity. Information regarding drugs (e.g., their administration, dosages, contraindications, adverse reactions, interactions, special warnings, and precautions) and drug delivery systems is subject to change, however, and the reader is advised to check the manufacturer’s package insert for information concerning recommended dosage and potential problems or cautions prior to dispensing or administering the drug or using the drug delivery systems.
Fair balance is achieved through ongoing and thorough review of all materials produced by faculty, and all educational and advertising materials produced by supporting organizations, prior to educational offerings. Approval of credit for this continuing education activity does not imply endorsement by AAPP for any product or manufacturer identified.