A pharmacy-based Vaccine Access Work Group, consisting of representatives from a diverse group of 13 organizations across pharmacy practice settings (including AAPP), jointly published guiding principles for state policy on pharmacy personnel–administered vaccines. This marks an unprecedented level of collaboration between pharmacy professionals, symbolizing a strong commitment from the field of pharmacy to national public health interests. In many states, the authority for pharmacists, pharmacy technicians, and pharmacy interns to administer vaccines is tied directly to recommendations from federal bodies such as the CDC, ACIP, and/or the FDA. As federal processes evolve, recommendations change, and advisory structures shift. Such references can create unintended legal and regulatory ambiguity, reduce flexibility, and delay access to newly authorized and existing vaccines. The core principles proposed in this document aim to address ambiguity in state policymaking regarding pharmacy personnel–administered vaccines, ultimately improving access to essential vaccinations for all Americans and providing guidance for structuring payment for pharmacist-provided services.