Treatment Guidelines: Seizure Disorders

American Academy of Neurology (AAN)

• Antiepileptic drug selection for people with HIV/AIDS (2012; reaffirmed 2024)
• Antiseizure Medication Withdrawal in Seizure-Free Patients: Practice Advisory Update Summary (2021)
• Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new-onset epilepsy (2018; reaffirmed 2021)
• Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs II: Treatment-resistant epilepsy (2018; reaffirmed 2021)
• Evidence-based guideline: Management of an unprovoked first seizure in adults (2015; reaffirmed 2024)
• Practice Parameter update: Management issues for women with epilepsy—Focus on pregnancy (2009; reaffirmed 2022)
• Clinical perspectives on medical marijuana (cannabis) for neurologic disorders (2015)
• Practice parameter: Treatment of the child with a first unprovoked seizure (2003; reaffirmed 2024)
• Teratogenesis, Perinatal, and Neurodevelopmental Outcomes After In Utero Exposure to Antiseizure Medication (2024)
• The use of Felbamate in the treatment of patients with intractable epilepsy (1999; reaffirmed 2022)

American Epilepsy Society (AES)

• Treatment of refractory convulsive status epilepticus (2020)
• Evidence-based guideline: Treatment of convulsive status epilepticus in children and adults (2016)

International League Against Epilepsy (ILAE)

• Barriers to generic antiseizure medication use: results of a global survey by the International League Against Epilepsy Generic Substitution Task Force (2022)
• FDA safety warning on the cardiac effects of lamotrigine: an advisory from the Ad Hoc ILAE/AES Task Force (2021)
• Management of epilepsy in pregnancy: A report from the International League Against Epilepsy Task Force on Women and Pregnancy (2019)
• Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes (2013)
• Antiepileptic drugs and suicidality: An expert consensus statement (2013)
• Antiepileptic drugs – Best practice guidelines for therapeutic drug monitoring (2008)

National Institute for Health and Care Excellence (NICE)

• Epilepsies in Children Young People and Adults (2022)
• Cannabis-based medicinal products (2019; updated 2021)

Neurocritical Care Society

• Guidelines for the evaluation and management of status epilepticus (2012)

Reviewer 1: Claire Herbst, PharmD, BCPS, BCPP
Reviewer 2: Austin Smith, PharmD, BCPP
2024-2025 AAPP Resident and New Practitioner Committee