Treatment Guidelines: Seizure Disorders

American College of Emergency Physicians (ACEP)

• Clinical policy: critical issues in the management of adult patients presenting to the emergency department with seizures (2024)

American Academy of Neurology (AAN)

• Management of functional seizures practice guideline executive summary (2025)
• Antiseizure medication withdrawal in seizure-free patients: practice advisory update summary (2021; reaffirmed 2025)  
• The use of felbamate in the treatment of patients with intractable epilepsy (1999; reaffirmed 2025) 
• Practice parameter update: management issues for women with epilepsy—focus on pregnancy (an evidence-based review): vitamin K, folic acid, blood levels, and breastfeeding (2009; reaffirmed 2025) 
• Teratogenesis, perinatal, and neurodevelopmental outcomes after in utero exposure to antiseizure medication (2024) 
• Antiepileptic drug selection for people with HIV/AIDS (2012; reaffirmed 2024) 
• Evidence-based guideline: management of an unprovoked first seizure in adults (2015; reaffirmed 2024) 
• Efficacy and tolerability of the new antiepileptic drugs I: treatment of new-onset epilepsy (2018; reaffirmed 2024) 
• Efficacy and tolerability of the new antiepileptic drugs II: treatment-resistant epilepsy (2018; reaffirmed 2024) 
• Practice parameter: treatment of the child with a first unprovoked seizure (2003; reaffirmed 2024) 
• Clinical perspectives on medical marijuana (cannabis) for neurologic disorders (2015)

American Epilepsy Society (AES)

• American Epilepsy Society clinical practice guideline: infantile epilepsy (2026)
• Treatment of refractory convulsive status epilepticus (2020)
• Evidence-based guideline: Treatment of convulsive status epilepticus in children and adults (2016)

International League Against Epilepsy (ILAE)

• Management of epilepsy in pregnancy: A report from the International League Against Epilepsy Task Force on Women and Pregnancy (2019)
• Antiepileptic drugs and suicidality: An expert consensus statement (2013)
• Antiepileptic drugs – Best practice guidelines for therapeutic drug monitoring (2008)

National Institute for Health and Care Excellence (NICE)

• Epilepsies in children, young people and adults (2022; updated 2026)
• Cannabis-based medicinal products (2019; updated 2021)

Neurocritical Care Society

• Guidelines for seizure prophylaxis in patients hospitalized with nontraumatic intracerebral hemorrhage: a clinical practice guideline for health care professionals rom the neurocritical care society (2024)
• Guidelines for seizure prophylaxis in adults hospitalized with moderate-severe traumatic brain injury: a clinical practice guideline for health care professionals from the neurocritical care society (2024)

Reviewer 1: Miranda Johnson, PharmD, BCPP
Reviewer 2: Roisin Sabol, PharmD, BCPP
2026-2027 AAPP Resident and New Practitioner Committee