2023 Literature Analysis

Credit is awarded in the calendar year the assessment is completed. AAPP reports continuing credit for ACPE (CPE Monitor) and BCPP Recertification (BPS) within days of successful exam completion.

Target Audience

This self-study activity serves as an educational tool for pharmacists seeking Board Certified Psychiatric Pharmacist (BCPP) Recertification credit and other pharmacists and health care providers seeking advanced education in patient management, disease state management, information management, and health policy and practice management in the field of psychiatric pharmacy.

Course Requirements

To satisfactorily complete the recertification programming and receive BCPP Recertification and ACPE credit, candidates must meet the following requirements:

  • Register for this course.
  • Complete the pre-test before starting the activity.
  • Review the full content of the activity and reflect upon its teachings.
  • Abide by a confidentiality and honesty statement requiring individual completion of the course.
  • Complete the post-test at the end of the activity no later than the closing activity date.
  • Complete an activity evaluation form.
  • Wait for an official review of exam questions within 4 weeks following the closing date.
  • Receive a passing grade (78%).
  • Partial credit is not provided; your exam score must meet or exceed the cut-off score in order to receive the ACPE and BCP Recertification credit.
  • Learners who do not achieve a passing score on a post-activity assessment may appeal assessment questions and/or take a remediation assessment. View AAPP's Post-Activity Assessment Appeal and Remediation Policy.
  • Provide the necessary details in your profile to ensure correct reporting by AAPP to CPE Monitor.

Learning Objectives

Article NumberTopicArticle and Learning Objectives
1

How to compare results of placebo-controlled trials across different medications

Article 1 on “Using Matching-Adjusted Indirect Comparisons and Network Meta-analyses to Compare Efficacy of Brexanolone Injection with Selective Serotonin Reuptake Inhibitors for Treating Postpartum Depression” is complimented by a 1 hour recorded webinar by Dr. Roger Sommi, PharmD, BCPP, assisting you as the learner in making accurate interpretations of the article. You are encouraged to read the article first and then watch the webinar while keeping the article open for frequent referral back to sections as guided by Dr. Sommi.

Cooper, M.C., Kilvert, H.S., Hodgkins, P. et al. Using Matching-Adjusted Indirect Comparisons and Network Meta-analyses to Compare Efficacy of Brexanolone Injection with Selective Serotonin Reuptake Inhibitors for Treating Postpartum Depression. CNS Drugs 33, 1039–1052 (2019). https://doi.org/10.1007/s40263-019-00672-w

The Recertification Editorial Board generally avoids using industry-sponsored trials for our literature analysis product. This study compares data from Phase II and III brexanolone trials to published trials of pharmacotherapy for the same indication. Most studies of this type are completed by the manufacturer because individual patient data is needed for this type of comparison. As this article is accompanied by a webinar, potential areas of bias can be addressed.

  1. Describe statistical methods for comparing the relative effectiveness of medications in the absence of head-to-head clinical trial data.
  2. Identify features of and uses for indirect treatment comparisons.
  3. Describe the internal validity and generalizability of the design and outcomes of a study for treatment of postpartum depression which uses indirect treatment comparison methods to assess relative effectiveness.
2

Schizophrenia

Jürgens G, Andersen SE, Rasmussen HB, et al. Effect of Routine Cytochrome P450 2D6 and 2C19 Genotyping on Antipsychotic Drug Persistence in Patients With Schizophrenia: A Randomized Clinical Trial. JAMA Netw Open. 2020;3(12):e2027909. doi:10.1001/jamanetworkopen.2020.27909

  1. Explain the results of pharmacogenomic cytochrome P450 testing.
  2. Identify treatment and/or monitoring strategies guided by pharmacogenomic testing in patients with schizophrenia.
  3. Discuss the clinical utility, including potential limitations, of pharmacogenomic testing in patients with schizophrenia.
3

Suicide

Katz IR, Rogers MP, Lew R, et al. Lithium Treatment in the Prevention of Repeat Suicide-Related Outcomes in Veterans With Major Depression or Bipolar Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2022;79(1):24–32. doi:10.1001/jamapsychiatry.2021.3170

  1. Identify patient-specific factors that determine appropriate candidates for lithium augmentation to reduce suicide-related events.
  2. Describe factors that may influence the effectiveness of lithium augmentation to reduce suicide-related events in patients with bipolar disorder or depression.
  3. Discuss potential risks and benefits of lithium augmentation to reduce suicide-related events in patients with bipolar disorder or depression.
4

Migraine Consensus Guideline

Ailani J, Burch RC, Robbins MS; Board of Directors of the American Headache Society. The American Headache Society Consensus Statement: Update on integrating new migraine treatments into clinical practice. Headache. 2021 Jul;61(7):1021-1039. doi: 10.1111/head.14153. Epub 2021 Jun 23. PMID: 34160823.

  1. Select appropriate acute and/or preventive treatment of migraine headaches based on patient specific factors.
  2. Identify patients who are appropriate candidates for recently approved migraine treatments.
  3. Describe important components of a comprehensive migraine treatment plan.
  4. Identify adverse effects and/or risks associated with newer migraine treatments.
5

Transition in Care

Gryglewicz, K., Peterson, A., Nam, E., Vance, M. M., Borntrager, L., & Karver, M. S. (2021). Caring transitions—A care coordination intervention to reduce suicide risk among youth discharged from inpatient psychiatric hospitalization. Crisis: The Journal of Crisis Intervention and Suicide Prevention. Advance online publication. https://doi.org/10.1027/0227-5910/a000795

  1. Identify elements of transitions of care for suicide risk reduction in youth after psychiatric hospitalization.
  2. Describe outcomes of transitions of care intervention in youth after psychiatric hospitalization.
  3. Select factors that affect service utilization in transitional mental healthcare after psychiatric hospitalization.
6

Depression in Epilepsy

Mula M, Brodie MJ, deToffol B, Guekht A, Hecimovic H, Kanemoto K, et al. ILAE clinical practice recommendations for the medical treatment of depression in adults with epilepsy. Epilepsia. 2022;63:316–334. https://doi.org/10.1111/epi.17140

  1. Describe safety concerns with treatment options for depression in patients with epilepsy.
  2. Select a treatment for depression in patients with epilepsy.
  3. Identify potential drug interactions between psychiatric and antiseizure medications.
7

Anxiety Disorders

Jerome, L., Feduccia, A.A., Wang, J.B. et al. Long-term follow-up outcomes of MDMA-assisted psychotherapy for treatment of PTSD: a longitudinal pooled analysis of six phase 2 trials. Psychopharmacology 237, 2485–2497 (2020). https://doi.org/10.1007/s00213-020-05548-2

  1. Describe the efficacy of MDMA in MDMA-assisted psychotherapy for treatment of posttraumatic stress disorder (PTSD).
  2. Identify the potential benefits of MDMA-assisted psychotherapy in patients with PTSD.
  3. Identify potential harm and/or characteristics that increases the risks associated with MDMA-assisted psychotherapy for treatment of PTSD.
8

Buprenorphine Initiation and Dosing

Ahmed S, Bhivandkar S, Lonergan BB, Suzuki J. Microinduction of buprenorphine/naloxone: a review of the literature. Am J Addict. 2021;30(4):305-15.

  1. Identify the risks and/or benefits of buprenorphine microinduction in patients with opioid use disorder (OUD).
  2. Describe clinical scenarios appropriate for buprenorphine microinduction over traditional induction.
  3. Select appropriate buprenorphine induction protocols based on patient characteristics.

Continuing Education Credit and Disclosures

Activity Dates: 02/23/2023 - 11/30/2023
ACPE Contact Hours: 10
ACPE Number: 0284-0000-23-002-H01-P (Knowledge)
Nursing Credit Reminder: Note that ACPE credit is accepted for ANCC Certification Renewal and AANPCB advanced practice provider content. For specific questions related to your organization's acceptance of ACPE continuing education units, please contact your organization directly.

ACPEThe American Association of Psychiatric Pharmacists is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. The Literature Analysis product is an application-based program approved for 10 hours of ACPE credit. To receive ACPE credit, pharmacists completing this programming are required to complete an evaluation of the course as well as pass an online examination. BCPP Recertification credit is earned and reported within the year the assessment is successfully completed.

Board Certified Psychiatric Pharmacists (BCPPs) may also receive 10 hours of BCPP Recertification Credit for the Literature Analysis upon successful completion of an online examination.

The American Association of Psychiatric Pharmacists is approved as a Professional Development Provider for the Board Certified Psychiatric Pharmacist (BCPP) specialty by the Board of Pharmacy Specialties (BPS). This course is part of a 10 hour BCPP recertification product earned after successful completion of the associated BCPP recertification examination for the full product.

AAPP reports continuing credit for ACPE (CPE Monitor) and BCPP Recertification (BPS) within days of successful exam completion.

View AAPP's Privacy Policy

AAPP owns the copyright, is licensed or has received permissions for use of, or is otherwise permitted to use copyrighted materials within any CPE activity. Authors and speakers are required to obtain necessary copyright permissions for content in CPE activities. AAPP complies with copyright laws and regulations.

Questions? Contact AAPP.

View planning committee disclosures

2023 Recertification Editorial Board

Marissa Cullen, PharmD, BCPP
Clinical Pharmacist
UPMC Western Psychiatric Hospital
Pittsburgh, PA
No Relevant Financial Relationships to Disclose

Beth DeJongh, PharmD, BCPS, BCPP
 

Director of Continuing Professional Development
American Association of Psychiatric Pharmacists
Lincoln, NE
No Relevant Financial Relationships to Disclose
Alisha D. Donat, PharmD, BCPP
Clinical Pharmacy Specialist - Mental Health
South Texas Veterans Health Care System
San Antonio, TX
No Relevant Financial Relationships to Disclose
Traci M. Dutton, PharmD, BCPP, BCPS
Clinical Pharmacy Specialist - Mental Health; Program Director - PGY2 Psychiatric Pharmacy Residency
VA Tennessee Valley Healthcare System
Murfreesboro, TN
Employment: Tennessee Valley VA Healthcare System, Clinical Pharmacy Specialist - Mental Health, Member of VA PBM Educational Advisory
Committee which oversees Board Certification Study Groups

Megan J. Ehret, PharmD, BCPP, MS
BCPP Program Director
Professor
University of Maryland
Baltimore, MD
External Consultant Activities, Advisory Panels, Speakers Bureaus, etc.: Saladex Biomedical Consultant, Lexi-Comp Consultant/Reviewer,
SMI Adviser; Pharmacist Consultant
Educational Grants, Research Grants or Contracts: FDA/University of Maryland CERSI, Maryland Behavioral Health Department, NIH

Abigail Hampton, PharmD, BCPP
Psychiatric Clinical Pharmacist - Ambulatory
University of Kansas Health System
Kansas City, KS
No Relevant Financial Relationships to Disclose
Jordan Haygood, PharmD, BCPP
Clinical Pharmacy Specialist - Psychiatry
Medical University of South Carolina
Charleston, SC
No Relevant Financial Relationships to Disclose
Courtney A. Iuppa, PharmD, BCPP
Clinical Pharmacy Manager & Residency Program Director
Center for Behavioral Medicine
Kansas City, MO
No Relevant Financial Relationships to Disclose
Archana R. Jhawar, PharmD, BCPP
Clinical Pharmacist
Jesse Brown VAMC/ UIC College of Pharmacy
Chicago, IL
No Relevant Financial Relationships to Disclose
Dongmi Kim, PharmD, BCPP, BCPS
Assistant Clinical Professor
Fairleigh Dickinson University School of Pharmacy
Florham Park, NJ
No Relevant Financial Relationships to Disclose
Jamie C. Kneebusch, PharmD, BCPP, BCPS
Assistant Clinical Faculty
UC San Diego, Skaggs School of Pharmacy
La Jolla, CA
No Relevant Financial Relationships to Disclose
Amber R. Lemons, PharmD, BCPP
Director, Educational Strategy
Clinical Care Options
Littleton, CO
No Relevant Financial Relationships to Disclose
Linda D. Logan, PharmD, BCACP, BCPP, BCPS
Public Service Associate
University of Georgia
Athens, GA
Educational Grants, Research Grants or Contracts: HRSA Graduate Psychology Education Grant, CPNP Foundation Student Grant (Advisor),
UGA College Pharmacy Ansel Fund
Megan Maroney, PharmD, BCPP
Clinical Associate Professor
Ernest Mario School of Pharmacy at Rutgers, the State University of New Jersey
Long Branch, NJ
External Consultant Activities, Advisory Panels, Speakers Bureaus, etc.: Pharmacy Times - speaker and medical writing honoraria,
Otsuka Pharmaceuticals - Excel Speakers Bureau (former, through March 2022), Novus Medical Education - consultant/medical writing,
Boehringer Ingelheim - advisory board, Sunovion Pharmaceuticals - consultant/advisory board, Biogen and Sage Therapeutics - advisory board
Monica Mathys, PharmD, BCGP, BCPP
Professor
Texas Tech University School of Pharmacy
Dallas, TX
Non-Financial Interests: CPNP Foundation Board member
Jessica L. Mulhollan, PharmD, BCPP
Clinical Pharmacy Specialist, Substance Use Disorders and Mental Health Clinical Pharmacy Supervisor
Louis Stokes Cleveland VA Medical Center
Cleveland, OH
No Relevant Financial Relationships to Disclose
Kristen Neumeister, PharmD, BCPP
Clinical Pharmacist
North Texas State Hospital
Fort Worth, TX
No Relevant Financial Relationships to Disclose
Megan O'Connell, PharmD, BCPP
Advanced Practice Pharmacist - Psychiatry
University of Maryland - Clifton T. Perkins Hospital
jessup, MD
No Relevant Financial Relationships to Disclose
Melissa C. Palmer, PharmD, BCPP, BCPS
Clinical Pharmacy Specialist - Mental Health
Alaska VA Healthcare System
Anchorage, AK
No Relevant Financial Relationships to Disclose
Brittany L. Parmentier, PharmD, BCPS, BCPP
Clinical Pharmacy Specialist in Psychiatry
The Harris Center for Mental Health and IDD
Houston, TX
No Relevant Financial Relationships to Disclose
Jake R. Peters, PharmD, BCPP, BCPS
Assistant Professor of Pharmacy Practice/Clinical Pharmacy Specialist - Psychiatry
Butler University College of Pharmacy/Indiana University Health
Indianapolis, IN
No Relevant Financial Relationships to Disclose
Sarah J. Popish, PharmD, BCPP
VA PBM Academic Detailing Services, Program Manager
Department of Veterans Affairs
Sarasota, FL
No Relevant Financial Relationships to Disclose
Kara R. Wong, PharmD, BCPP
Chair
Clinical Pharmacist Practitioner, Mental Health
Minneapolis VA Health Care System
Minneapolis, MN
No Relevant Financial Relationships to Disclose

All relevant relationships have been mitigated.

All relevant relationships have been mitigated.

View disclaimer and disclosure of off-label use

Off-Label Use: This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA (see faculty information). The opinions expressed in the educational activity do not necessarily represent the views of AAPP and any educational partners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer: Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

View fair balance and integrity statement

It is the policy of AAPP to ensure independence, balance, objectivity, scientific rigor, and integrity in continuing education activities. Those involved in the development of this continuing education activity have made all reasonable efforts to ensure that information contained herein is accurate in accordance with the latest available scientific knowledge at the time of accreditation of this continuing education activity. Information regarding drugs (e.g., their administration, dosages, contraindications, adverse reactions, interactions, special warnings, and precautions) and drug delivery systems is subject to change, however, and the reader is advised to check the manufacturer’s package insert for information concerning recommended dosage and potential problems or cautions prior to dispensing or administering the drug or using the drug delivery systems.

Fair balance is achieved through ongoing and thorough review of all materials produced by faculty, and all educational and advertising materials produced by supporting organizations, prior to educational offerings. Approval of credit for this continuing education activity does not imply endorsement by AAPP for any product or manufacturer identified.

It is the policy of AAPP to ensure independence, balance, objectivity, scientific rigor, and integrity in their continuing education activities.

Those involved in the development of this continuing education activity have made all reasonable efforts to ensure that information contained herein is accurate in accordance with the latest available scientific knowledge at the time of accreditation of this continuing education activity. Information regarding drugs (e.g., their administration, dosages, contraindications, adverse effects, interactions, special warnings, and precautions) and drug delivery systems is subject to change, however, and the reader is advised to check the manufacturer's package insert for information concerning recommended dosage and potential problems or cautions before dispensing or administering the drug or using the drug delivery system.

Fair balance is achieved through ongoing and thorough review of all materials produced before educational offerings. Approval of credit for this continuing education activity does not imply endorsement by AAPP for any product or manufacturer identified.

In accordance with the Food and Drug Administration (FDA), it is disclosed that there is the potential for discussions concerning off-label uses of a commercial product/devices during this educational activity.

Any person who may contribute to the content of this continuing education activity must disclose significant relationships (and any known relationships of their spouse/partner) with commercial companies whose products or services are discussed in this activity. Significant relationships include receiving research grants, consultant fees, travel, other benefits from a commercial company, or having a self-managed equity interest in a company.

Disclosure of a relationship is not intended to suggest or condone any bias in any presentation but is made to provide participants with information that might be of potential importance to their evaluation of a presentation.

AAPP planners and managers have no relationships to disclose related to the content of this CE activity.