The Clozapine Rechallenge Dilemma: Who, When, and How?

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Disclosure Declaration: It is the policy of CME Outfitters, LLC to ensure independence, balance, objectivity, and scientific rigor, and integrity in all of their CE activities. Faculty must disclose to the participants any relationships with commercial companies whose products or devices may be mentioned in faculty presentations, or with the commercial supporter of this CE activity. CME Outfitters, LLC, has evaluated, identified, and mitigated any potential conflicts of interest through a rigorous content validation procedure, use of evidence-based data/research, and a multidisciplinary peer review process. The following information is for participant information only. It is not assumed that these relationships will have a negative impact on the presentations.  

Faculty for This Clozapine Module:

• Robert O. Cotes, MD discloses: Consultant – Saladax Biomedical, Clozapine Product Manufacturer’s Group, Boehringer Ingelheim; Research Support – Bristol Myers Squibb, Alkermes, Boehringer Ingelheim; Speakers Bureau – Saladax Biomedical, Clozapine Product Manufacturer’s Group, Boehringer Ingelheim

Planning Committee:

• Andria F. Church, PharmD, BCPP (AAPP) has nothing to disclose
• Candice Gillett, MPH (CMEO) has nothing to disclose

Peer Reviewers and Content Reviewers:

• Content Reviewer (AAPP) - Beth DeJongh, PharmD, FAAPP, BCPP, BCPS has nothing to disclose
• Content Reviewer (CMEO) - Scott J. Hershman, MD, FACEHP, CHCP has nothing to disclose
• Peer Reviewer - Kristen Choi, PhD, PMHNP-BC, FAAN has nothing to disclose
• Peer Reviewer - Chad Koyanagi, MD has nothing to disclose
• Peer Reviewer - Michael Shuman, PharmD, BCPP has nothing to disclose

 Disclosures were obtained from the CME Outfitters, LLC staff: Nothing to disclose.
*All identified conflicts of interest have been mitigated.

Unlabeled Use Disclosure: Faculty of this CME/CE activity may include discussions of products or devices that are not currently labeled for use by the FDA. The faculty have been informed of their responsibility to disclose to the audience if they will be discussing off-label or investigational uses (any uses not approved by the FDA) of products or devices. CME Outfitters, LLC, the faculty, planners, and American Association of Psychiatric Pharmacists do not endorse the use of any product outside of the FDA labeled indications. Medical professionals should not utilize the procedures, products, or diagnosis techniques discussed during this activity without evaluation of their patient for contraindications or dangers of use. 

Disclaimer: Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

It is the policy of AAPP to ensure independence, balance, objectivity, scientific rigor, and integrity in continuing education activities. Those involved in the development of this continuing education activity have made all reasonable efforts to ensure that information contained herein is accurate in accordance with the latest available scientific knowledge at the time of accreditation of this continuing education activity. Information regarding drugs (e.g., their administration, dosages, contraindications, adverse reactions, interactions, special warnings, and precautions) and drug delivery systems is subject to change, however, and the reader is advised to check the manufacturer’s package insert for information concerning recommended dosage and potential problems or cautions prior to dispensing or administering the drug or using the drug delivery systems.

Fair balance is achieved through ongoing and thorough review of all materials produced by faculty, and all educational and advertising materials produced by supporting organizations, prior to educational offerings. Approval of credit for this continuing education activity does not imply endorsement by AAPP for any product or manufacturer identified.