Treatment Guidelines: Sleep-Wake Disorders

Insomnia

American Academy of Neurology (AAN)

• Treatment for insomnia and disrupted sleep behavior in children and adolescents with autism spectrum disorder (2020)

American Academy of Sleep Medicine (AASM)

• Clinical practice guideline for the pharmacologic treatment of chronic insomnia in adults (2017)

American College of Physicians (ACP)

• Management of chronic insomnia disorder in adults (2016)

European Sleep Research Society (ESRS)

• The European insomnia guideline: An update on the diagnosis and treatment of insomnia (2023)

Veteran Affairs/Department of Defense

• The Management of Chronic Insomnia Disorder and Obstructive Sleep Apnea (2025)

Obstructive Sleep Apnea

American Academy of Sleep Medicine (AASM)

• Treatment of adult obstructive sleep apnea with positive airway pressure (2019)
• The treatment of central sleep apnea syndromes in adults: Practice parameters with an evidence-based literature review and meta-analyses (2012)
• Evaluation, management, and long-term care of obstructive sleep apnea in adults (2009)
• Practice parameters for the medical therapy of obstructive sleep apnea (2006)

American College of Physicians (ACP)

• Management of obstructive sleep apnea in adults (2013)

Japanese Respiratory Society

• Sleep apnea syndrome (SAS) clinical practice guidelines (2020)

Spanish Society of Pulmonary and Thoracic Surgery (SEPAR)

• International consensus document on obstructive sleep apnea (2022)

Veteran Affairs/Department of Defense

• The Management of Chronic Insomnia Disorder and Obstructive Sleep Apnea (2025)

Restless Leg Syndrome

American Academy of Neurology (AAN)

• Treatment of restless legs syndrome in adults (2016)

American Academy of Sleep Medicine (AASM)

• Treatment of restless leg syndrome and periodic limb movement disorder: an American Academy of Sleep Medicine clinical practice guidelines (2025)

European Academy of Neurology (EAN)

• European guidelines on management of restless legs syndrome (2012)

Central Hypersomnolence

American Academy of Sleep Medicine (AASM)

• Treatment of central disorders of hypersomnolence (2021)

Miscellaneous

American Academy of Sleep Medicine (AASM)

• Management of REM sleep behavior disorder (RBD) (2023)
• Position paper for the treatment of nightmare disorder in adults (2018)
• Clinical practice guideline for the treatment of intrinsic circadian rhythm sleep-wake disorders: Advanced sleep-wake phase disorder (ASWPD), delayed sleep-wake phase disorder (DSWPD), Non-24-hour sleep-wake rhythm disorder (N24SWD), and irregular sleep-wake rhythm disorder (ISWRD) (2015)

British Association for Psychopharmacology (BAP)

• Consensus statement of evidence-based treatment of insomnia, parasomnias, and circadian rhythm disorders: An update (2019)

European Academy of Neurology (EAN)

• EAN/ERS/ESO/ESRS statement on the impact of sleep disorders on risk and outcome of stroke (2020)

Reviewer 1: Allison Beatty, PharmD, BCPP
Reviewer 2: Austin Smith, PharmD, BCPP
2025-2026 AAPP Resident and New Practitioner Committee