Treatment Guidelines: Neuropathic Pain

American Academy of Neurology (AAN) 

• Oral and topical treatment of painful diabetic polyneuropathy practice guidelines (2021; reaffirmed 2025)

American Academy of Pain Medicine (AAPM)

• Complex regional pain syndrome: practical diagnostic and treatment guidelines, 5th edition (2022)

American Diabetes Association

• Diabetic neuropathy: a position statement by the American Diabetes Association (2016)

Canadian Pain Society 

• Evidence-based guideline for neuropathic pain interventional treatments: spinal cord stimulation, intravenous infusions, epidural injections and nerve blocks (2012)

Centers for Disease Control and Prevention (CDC)

• CDC Clinical Practice Guideline for Prescribing Opioids for Pain — United States (2022)

European Federation of Neurological Societies (EFNS)/Peripheral Nerve Society (PNS)

• Guideline on diagnosis and treatment of Guillain–Barré syndrome (2023)
• Guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint task force—second revision (2021)
• Guideline on management of multifocal motor neuropathy (2010)
• Guideline on management of paraproteinemic demyelinating neuropathies (2010)

Infectious Diseases Society of America (IDSA)/HIV Medicine Association (HIVMA)

• HIVMA of IDSA clinical practice guideline for the management of chronic pain in patients living with HIV (2017)

International Association for the Study of Pain Neuropathic Pain Special Interest Group (NeuPSIG)

• Interventional management of neuropathic pain: NeuPSIG recommendations (2015)

National Institute for Health and Care Excellence (NICE) 

• Neuropathic pain in adults: pharmacological management in non-specialist settings (2020)

Toronto Expert Panel on Diabetic Neuropathy

• Painful diabetic peripheral neuropathy – Consensus recommendations on diagnosis, assessment and management (2011)

U.S. Department of Health & Human Services 

• Pain management best practices inter-agency task force report (2019)

Veterans Affairs/Deparate of Defense (VA/DoD)

• Clinical Practice Guidelines for the use of opioids in the management of chronic pain (2022)

Reviewer 1: Arianna Johnson, PharmD, BCPP
Reviewer 2: Roisin Sabol, PharmD, BCPP
2026-2027 AAPP Resident and New Practitioner Committee