Treatment Guidelines: Anxiety and Related Disorders

Agency for Healthcare Research and Quality (AHRQ)/ Patient-Centered Outcomes Research Institute (PCORI)

• Pharmacologic and nonpharmacologic treatments for posttraumatic stress disorder: an update of the PTSD repository evidence base (2025)

American Academy of Child and Adolescent Psychiatry (AACAP)

• Clinical practice guideline for the assessment and treatment of children and adolescents with anxiety disorders (2020)
• Practice parameter for the assessment and treatment of children and adolescents with obsessive-compulsive disorder (2012)

American Academy of Family Physician (AAFP)

• Generalized anxiety disorder and panic disorder in adults (2022)

American Psychiatric Association (APA)

• Practice guideline for the treatment of patients with panic disorder (2009)    
• Practice guideline for the treatment of patients with acute stress disorder and posttraumatic stress disorder (2004, with 2009 guideline watch)    
• Practice guideline for the treatment of patients with obsessive compulsive disorder (2007, with 2013 guideline watch)

American Psychological Association

• Clinical Practice Guideline for the Treatment of PTSD in Adults (2025)    

Canadian Anxiety Disorders Initiative

• Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders (2014)

British Association for Psychopharmacology (BAP)

• Evidence-based pharmacological treatment of anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder (2014)

Canadian Network for Mood and Anxiety Treatments

• Canadian Network for Mood and Anxiety Treatments (CANMAT) and International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) 2025 international guidelines for the management of patients with obsessive-compulsive disorder (2025)
• Perinatal mood, anxiety and related disorders (2024)

National Institute for Health and Care Excellence (NICE)

• Generalised anxiety disorder and panic disorder in adults: management (2020)  
• Post-traumatic stress disorder: management (2018)  
• Social anxiety disorder: recognition, assessment, and treatment (2013)  
• Obsessive-compulsive disorder and body dysmorphic disorder: treatment (2005)  
  • Update in progress: Expected publication date: 16 February 2027

Phoenix Australia – Centre for Posttraumatic Mental Health

• Australian Guidelines for the Prevention and Treatment of Acute Stress Disorder, Posttraumatic Stress Disorder and Complex PTSD (2021)

Veterans Affairs/Department of Defense

• Clinical practice guideline for management of post-traumatic stress disorder and acute stress disorder (2023)

World Federation of Societies of Biological Psychiatry (WFSBP)

• Guidelines for the pharmacological treatment of anxiety disorders, obsessive – compulsive disorder and posttraumatic stress disorder in primary care (2012)
• Guidelines for treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders – Version 3. Part 1: Anxiety Disorders (2002, updated 2022) 
• Guidelines for treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders – Version 3. Part 11: OCD and PTSD (2002, updated 2022) 

Reviewer 1: Mitchell Crouch, PharmD, BCPP
Reviewer 2: Roisin Sabol, PharmD, BCPP
2026-2027 AAPP Resident and New Practitioner Committee