If you are a pharmacist, nurse practitioner, or other health care professional involved in the comprehensive medication management of individuals living with mental health and/or substance use disorders, we invite you to participate in this online course.
Session Summary
In the era of shared decision-making, ensuring patients and families understand the relative risk and statistical concept of number needed to treat for understanding efficacy and side effect liabilities may help empower patients to improve adherence. This program will help ensure psychiatric pharmacists and other health care professionals using antipsychotic treatments understand the benefits and drawbacks to newer antipsychotics and can help best place these “third-generation” antipsychotic treatments in treatment plans that may improve overall patient outcomes.
Course Requirements
To receive ACPE credit for this session, you must:
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Register for this course.
Complete the pre-test before starting the activity.
Review the full content of the activity and reflect upon its teachings.
Complete the post-test at the end of the activity no later than the closing activity date.
Complete the evaluation at the end of the activity.
If necessary, complete the post-test retest no later than the closing activity date.
Receive a passing grade (70%).
Provide the necessary details in your profile to ensure correct reporting by AAPP to CPE Monitor.
Participants in this course must complete an examination and achieve a score of 70% or greater. Up to two exam attempts are provided to each participant. Successful completion of the course also requires the completion of a course evaluation. Upon successful completion, ACPE credit is reported immediately to CPE Monitor although transcripts can be retrieved by participants online at https://aapp.org/mycpnp/transcript/acpe.
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Faculty Information and Disclosures
Leslie Citrome, MD, MPH Steven C. Stoner, PharmD, BCPP
Speaker
Leslie Citrome, MD, MPH
Clinical Professor, Psychiatry and Behavioral Sciences
New York Medical College
Valhalla, New York
President, American Society of Clinical Psychopharmacology
Dr. Citrome is clinical professor of psychiatry and behavioral sciences at New York Medical College in Valhalla, New York, clinical professor of psychiatry at SUNY Upstate Medical University, and adjunct clinical professor of psychiatry, Icahn School of Medicine at Mount Sinai in New York City, New York. He is a Distinguished Life Fellow of the American Psychiatric Association and a Fellow of the American Society of Clinical Psychopharmacology where he currently serves as President. In addition to his academic positions, he has a private practice in psychiatry in Pomona, New York and is a volunteer consultant to the Assertive Community Treatment team/Mental Health Association of Rockland County. In 2019 he received the New York Medical College Faculty Author Award for “First Authorship Who Published in the Most Open Access Journals (Web of Science),” and in 2018 and 2021 was recognized as the Voluntary Faculty Teacher of the Year, Department of Psychiatry and Behavioral Sciences, New York Medical College/Westchester Medical Center.
Dr. Citrome obtained his MD degree from the McGill University Faculty of Medicine in 1983 and his MPH degree from the Columbia School of Public Health in 1996. His immediate prior position was as the founding Director of the Clinical Research and Evaluation Facility at the Nathan S. Kline Institute for Psychiatric Research in Orangeburg, New York, where he worked from 1994 through 2010 and achieved the rank of Professor of Psychiatry at the New York University School of Medicine.
Dr. Citrome is currently a consultant in clinical trial design and interpretation. He is a frequent lecturer on the quantitative assessment of clinical trial results, including the metrics of number needed to treat and number needed to harm, and has lectured throughout the Americas, Europe, Asia, and Australasia. His main interests include schizophrenia, bipolar disorder, and major depressive disorder. He is author or coauthor of over 550 research reports, reviews, and chapters in the scientific literature. Dr. Citrome is editor emeritus, International Journal of Clinical Practice where he was editor-in-chief 2013-2019; psychiatry topic editor for Clinical Therapeutics; editor for the American Society of Clinical Psychopharmacology Corner in the Journal of Clinical Psychiatry; section editor for psychopharmacology for Current Psychiatry; and also serves as an editorial board member for CNS Spectrums, Expert Review of Neurotherapeutics, Neurology and Therapy, Clinical Psychopharmacology and Neuroscience, Annals of Clinical Psychiatry, Expert Opinion on Drug Safety, Current Drug Safety, Schizophrenia Research and Treatment, Postgraduate Medicine, Journal of Clinical Psychopharmacology, Clinical Practice, Medscape Psychiatry & Mental Health.
Disclosures
Consultant: AbbVie/Allergan, Acadia, Adamas, Alkermes, Angelini, Astellas, Avanir, Axsome, BioXcel, Boehringer Ingelheim, Cadent Therapeutics, Eisai, Enteris BioPharma, HLS Therapeutics, Impel, Intra-Cellular Therapies, Janssen, Karuna, Lundbeck, Lyndra, Medavante-ProPhase, Merck, Neurocrine, Novartis, Noven, Otsuka, Ovid, Relmada, Reviva, Sage, Sunovion, Teva, University of Arizona, and one-off ad hoc consulting for individuals/entities conducting marketing, commercial, or scientific scoping research
Speakers Bureau/Educational Services: AbbVie/Allergan, Acadia, Alkermes, Angelini, Eisai, Intra-Cellular Therapies, Janssen, Lundbeck, Neurocrine, Noven, Otsuka, Sage, Sunovion, Takeda, Teva, and CME activities organized by medical education companies such as Medscape, NACCME, NEI, Vindico, and Universities and Professional Organizations/Societies
Financial: Royalties: Wiley (Editor-in-Chief, International Journal of Clinical Practice, through end 2019), UpToDate (reviewer), Springer Healthcare (book), Elsevier (Topic Editor, Psychiatry, Clinical Therapeutics)
My presentation will include discussion of off-label, experimental, and /or investigational use of drugs or devices: Novel agents being developed for the treatment of schizophrenia such as TAAR1 receptor modulators and muscarinic receptor modulators.
Major Stock Holder: Stocks (small number of shares of common stock): Bristol-Myers Squibb, Eli Lilly, J & J, Merck, Pfizer purchased > 10 years ago
Speaker and Activity Chair
Steven C. Stoner, PharmD, BCPP
Associate Dean for Student Affairs, Clinical Professor
University of MO at KC School of Pharmacy
Kansas City, MO
This presentation will include discussion of off-label, experimental, and/or investigational use of drugs or devices: Ulotaront; Ralmitaront
All relevant relationships have been mitigated.
Learning Objectives
Discuss the receptor binding profile of trace amine associated receptor 1 (TAAR1) agonists in development and compare findings to first and second-generation antipsychotics.
Summarize the relationship between trace amines and TAAR1 receptors in cell signaling.
Discuss mechanistic theories as to how TAAR1 agonist activity downregulates dopamine transmission and may be useful in the future treatment of schizophrenia.
Review the findings of available clinical trial data regarding the safety and efficacy of TAAR1 agonists in the treatment of schizophrenia.
Continuing Education Credit and Disclosures
Activity Dates: 02/23/2022 - 02/23/2024 ACPE Contact Hours: 1 ACPE Number: 0284-0000-22-060-H01-P (Knowledge) Nursing Credit Reminder: Note that ACPE credit is accepted for certification renewal.
The College of Psychiatric and Neurologic Pharmacists is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.
Off-Label Use: This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA (see faculty information and disclosures). The opinions expressed in the educational activity do not necessarily represent the views of AAPP and any educational partners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Disclaimer: Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Presentation-Specific Disclosure: My presentation will include discussion of off-label, experimental, and /or investigational use of drugs or devices: Novel agents being developed for the treatment of schizophrenia such as TAAR1 receptor modulators and muscarinic receptor modulators.
It is the policy of AAPP to ensure independence, balance, objectivity, scientific rigor, and integrity in continuing education activities. Those involved in the development of this continuing education activity have made all reasonable efforts to ensure that information contained herein is accurate in accordance with the latest available scientific knowledge at the time of accreditation of this continuing education activity. Information regarding drugs (e.g., their administration, dosages, contraindications, adverse reactions, interactions, special warnings, and precautions) and drug delivery systems is subject to change, however, and the reader is advised to check the manufacturer’s package insert for information concerning recommended dosage and potential problems or cautions prior to dispensing or administering the drug or using the drug delivery systems.
Fair balance is achieved through ongoing and thorough review of all materials produced by faculty, and all educational and advertising materials produced by supporting organizations, prior to educational offerings. Approval of credit for this continuing education activity does not imply endorsement by AAPP for any product or manufacturer identified.
Grant Support
This activity is supported by an educational grant from Sunovion Pharmaceuticals Inc.
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The College of Psychiatric and Neurologic Pharmacists is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.